|
Search | Add a publication |
| ID No : | 878 Edit | Title: | Toxicity of Lunar Dust in Lungs Assessed by Examining Biomarkers in Exposed Mice |
| Summary / Review : | "NASA is contemplating to build an outpost on the Moon for prolonged human habitation and research. The lunar surface is covered by a layer of soil, of which the finest portion is highly reactive dust. Dust samples of respirable sizes were aerodynamically isolated from two lunar soil samples of different maturities (cosmic exposure ages) collected during the Apollo 16 mission. The lunar dust samples, TiO2, or quartz, suspended in normal saline were given to groups of 5 C57 male mice by intrapharyngeal aspiration at 0. 1, 0.3, or 1.0 mg/mouse. Because lunar dust aggregates rapidly in aqueous media, some tests were conducted with dusts suspended in Survanta/saline (1:1). The mice were euthanized 7 or 30 days later, and their lungs were lavaged to assess the presence of toxicity biomarkers in bronchioalveolar lavage fluids. The overall results showed that the two lunar dust samples were similar in toxicity, they were more toxic than T102 , but less toxic than quartz. This preliminary study is a part of the large study to obtain data for setting exposure limits for astronauts living on the Moon" (Author's abstract) |
| Author(s) : |
Lam, C.-W.; James, J. T.; Zeidler-Erdely, P. C.; Castranova, V.; Young, S. H.; Quan, C. L.; Khan-Mayberry, N.; Taylor, L. A., [Johnson Space Center] |
| Publication Date: | 2010 |
| Category(s) : |
Life / Health human / Lunar dust |
| Progress Type: | T ( A=Analysis only, D=Design, T=Testing, C=Completed or Commercial product ) |
| Web URL : |
http://hdl.handle.net/2060/20100011075
If this link is broken, please Add Comment below. We try to keep author contact details, and a backup copy in our offline library. |
| PERMANENT code(s) : | L,U |
|
(Explanation of the last 3 rows above) |
In the row above, there are up to 4 possibilities: U = URL you can click on to get a copy instantly from another source on the internet, or request it from that source D = Downloadable from PERMANENT (such as because no other URL known...) L = LAN copy, PERMANENT has a digital copy but not downloadable from our website P = Paper copy in the PERMANENT office Typically, only 0 to 3 methods are available. |
| NTRS : | 20100011075 |
| Other Ref # : | JSC-CN-20056 |
| Submitted by : | MEP |
| Comments: |
Please add your thoughtful Comments to this paper after reading it. All comments are reviewed and approved before being posted publicly below. If you wish to submit a private comment to the curator, instead of a public comment, just write "Private" at the start of your comment. Corrections and suggested additions to our records are appreciated. |
Add Comment |